Polish flag carrier LOT will begin flights to San Francisco from Warsaw on 5 August 2020.
The route will be operated four times a week with Boeing 787s, Star Alliance member LOT says.
Noting that the route launch coincides with Poland being added to the USA's visa waiver programme, LOT chief executive Rafal Milczarski states: "We do believe that now Poles will be more willing to travel to the United States for both tourist and business purposes."
Together with the San Francisco service, LOT will offer a total 11 direct routes to US destinations from Warsaw, Krakow, Rzeszow, and Hungarian capital Budapest.
"Each year, nearly 300,000 passengers travel between central and eastern Europe and San Francisco, and I do believe that with our connection this figure will grow even further," Milczarski says.
San Francisco will become LOT's 20th long-haul service, following the launch of routes from Warsaw to Beijing and from Krakow to New York, which are set to begin later this month and in May 2020, respectively.